Overview

Macromolecular structure determination is moving from a functionally driven initiative to include a genomically driven initiative (structural genomics) where structures are determined based on what is known from a target sequence alone. The resultant structures may be structurally and functionally uncharacterized. Systematic Protein Annotation and Modeling (SPAM) is a multi-institutional initiative to make better use of target sequences and structures. SPAM includes new algorithms for the study of sequence-sequence, sequence-structure and structure-structure and deployment of these methods in resources available to the community